antiphospholipid antibody test

Antiphospholipid antibody syndrome is an autoimmune disorder in which the body's immune system makes antibodies that attack phospholipids, causing cell damage and blood clots. Available online at http://emedicine.medscape.com/article/261691-overview. National Heart Lung and Blood Institute [On-line information]. What are antiphospholipid antibodies? Antiphospholipid syndrome (APS), also called Hughes syndrome, is a recognized group of signs and symptoms that includes the formation of blood clots, miscarriages, platelet deficiency (thrombocytopenia), and the presence of one or more antiphospholipid antibodies. The information provided through this Service is not intended to substitute for such consultations with your physician nor specific medical advice to your health condition. When a person with a diagnosed autoimmune disorder tests negative for antiphospholipid antibodies, one or more of the tests may be repeated at regular intervals to screen for the development of an antiphospholipid antibody. Davis Company, Philadelphia, PA [18th Edition]. When antiphospholipid antibodies are produced, they interfere with the clotting process. It also may be ordered when a woman has had recurrent miscarriages and/or as a follow-up to a prolonged PTT test. Antiphospholipid syndrome (APS) is an autoimmune disorder, meaning that the body's immune system makes proteins known as antibodies that mistakenly attack its own cells or tissues. Antiphospholipid Antibodies: Anticardiolipin Antibodies and the Lupus Anticoagulant in Systemic Lupus Erythematosus. The Laboratory Test Handbook, 5th Edition. Normally, two of these tests (the apt and the RVVT) are performed to detect whether lupus anticoagulant is present. Antiphospholipid syndrome is an immune disorder in which abnormal antibodies are linked to abnormal blood clots in veins and arteries. Occasionally, antiphospholipid antibody testing may be ordered to help determine the cause of a positive VDRL/RPR test for syphilis. Some examples are: The presence of phospholipid antibodies in some instances may be temporary and they have been identified in some individuals who have no detectable illnesses. However, you are currently at Lab Tests Online. Tripodi A. A diagnosis of APS can only be made after 2 abnormal blood test results, with at least a 12-week gap between them. Other antiphospholipid antibodies include anti-beta 2 glycoprotein 1 (anti-ß2 GPI), anti-prothrombin, and the “false-positive” test for syphilis. To help investigate the presence of blood clots or an unexpectedly prolonged PTT (partial thromboplastin time), especially if you have had recurrent miscarriages; as part of an evaluation for antiphospholipid syndrome (APS); sometimes to help diagnose or evaluate an autoimmune disorder, When you have an unexplained prolonged PTT test; when you have had recurrent unexplained blood clots; when you have had recurrent miscarriages, especially in the second and third trimesters, A blood sample drawn from a vein in your arm. Available online at http://www.apsfa.org/aps.htm. Accessed on 4/12/08. © 2021 LabTestsOnline.org. Transient antiphospholipid antibodies may be seen in people who have inflammation, autoimmune disorders, infections, or cancer. There are different classes (isotypes) of anticardiolipin antibody, namely IgG, IgM, and IgA. NINDS Antiphospholipid Syndrome Information Page. Accessed January 2013. If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range. The syndrome is associated with risk of inappropriate blood clot formation, so it is considered an excessive clotting disorder (thrombophilia). It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits.". Rodgers, G. et. One can test for all isotypes at once, or they can be detected separately. The syphilis test of those days—the Wasserman test—was dependant on an antibody found in syphilis patients called reagin. © 2008).]. Complications of antiphospolipid antibodies in lupus include fetal loss and/or miscarriages, blood clots of the veins or arteries (thromboses), low platelet counts (autoimmune thrombocytopenia), strokes, transient ischemic attacks (stroke warnings), Libman-Sacks endocarditis (formation of a clot on a specific heart valve), pulmonary emboli, and pulmonary hypertension.

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